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The gift of Haelan
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Excerpts From Well Being Journal Vol. 11, No. 6 ~
November/December 2002 Haelan951 is a fermented soy supplement made by Haelan951 Products Inc. based in Seattle, USA. Manufacturing, which includes plant cultivation and processing of the soybeans, is done in the People's Republic of China. The patented fermentation process involved in the manufacture of Haelan951 hydrolyzes many of the soybean proteins into amino acids and compounds that are rich in nitrogen, polysaccharides and fermentation metabolites of the naturally occurring isoflavones, protease inhibitors, saponins, phytosterols and inositol hexaphosphate compounds in soybeans. The unique process uses the autogenic antiammonia azotobacter mutant strain, induced from Azotobacter vinelandii as inoculum in an industrial fermentation. They are specific bacterial strains belonging to the species Stenotrophomonas maltophilia Q-can. The soy beverage is a concentrated nutritional supplement that is rich in soybean proteins, selenium, zinc, beta-carotene (vitamin A), riboflavin (vitamin B1), thiamine (vitamin B2), cyanocobalamin (vitamin B12), ascorbate (vitamin C), cholecalciferol (vitamin D3), alpha tocopherol (vitamin E) and phylloquinone (vitamin K1). It also contains additional micronutrients such as daidzein, genistein, protease inhibitors, saponins, phytosterols and inositol hexaphosphate, and essential fatty acids such as linolenic and linolic acids, polysaccharide peptide, and twenty of the twenty-two amino acids, including ornithine.(54) It takes over 25 pounds of soybeans to make one concentrated eight-ounce bottle of the Haelan951 beverage. Of these naturally occurring nutritional items in the Haelan951 formula, more than 20 of them are known individually for their ability to enhance the nutritional profiles of individuals with cancers. Over the last 16 years there have been a number of investigations done to examine the active components in the fermentated soy solution that play a major role in killing carcinogenic cells. There have been a few pilot studies that have reported on the anti-oxidant properties of soy isoflavones, especially genistein. It is postulated that the soy supplementation decreases levels of oxidative DNA damage in humans and that this may be one of the mechanisms behind the anti-carcinogenic effects of soy isoflavones. Some of the clinical trials done so far have indicated that although some of the soy isoflavones such as daidzein, genistein and saponins may have contributed to the anticarcinogenic activities of the fermented soy beverage, there are also studies that have isolated branched chain fatty acids called small biosynthetic anticancer agents (SBAs) from Haelan that have significant tumor-inhibition effects. Further research on these compounds has indicated that the mechanism of action of these specific branched–chain fatty acids is associated with the induction of programmed cell death (apoptosis). But, just as importantly, it was observed that the specific branched fatty acids do not kill normal cells but inhibit the growth of cancer cells without any toxic effects. Case Report Mr. SL is a 58-year-old African American who presented 3 years ago with a gradual rise in his PSA levels. When he saw his primary care physician in September 1999, his PSA was 2.9 ng/ml (normal < 4.0). Clinically he had complaints of frequency of micturition at night for the preceding one week. Pre-rectal examination revealed a suspicious nodule in the prostate gland. A biopsy was taken and came back as being positive for infiltrating adenocarcinoma with a Gleason score 6. The report also indicated the presence of benign prostatic hyperplasia and focal chronic prostatitis. Mr. SL started on Haelan951 2 weeks after his diagnosis of prostate cancer. His urologist strongly recommended a radical perineal prostatectomy. He was also given an option for brachytherapy. The patient refused both options and instead opted to continue with Haelan951 and herbal supplements. Mr. SL initially started with 8 oz of Haelan in 2 divided doses per day for a period of 3 to 4 months and then tapered to 4 oz a day in 2 divided doses for a duration of a year. He is presently on a maintenance dose of 2 oz a day. He also switched to a more vegetarian, fruits and fish based diet after his diagnosis of prostate cancer. Over the last 3 years, Mr. SL's PSA levels have remained stable at values around 3.5 or less than 4.0 ng/ml, which is within normal for his condition. His last clinical and rectal examination in November 2001 did not reveal anything abnormal with his prostate gland. The last two pelvic sonagrams or doppler prostate and pelvic vascular ultrasound done in 2000 and in 2001 were normal. Mr. SL is currently doing well.
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